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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Persicarin</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable infobox float-right" id="Vorlage_Infobox_Chemikalie" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Chemikalie">
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Strukturformel
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Allgemeines
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<td style="width:33%;">Name
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<td>Persicarin
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<td>Andere Namen
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<p>5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4<i>H</i>-chromen-3-ylhydrogensulfat (<a href="IUPAC-Nomenklatur" class="mw-redirect" title="IUPAC-Nomenklatur">IUPAC</a>)
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<td><a href="Summenformel" title="Summenformel">Summenformel</a>
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<td>C<sub>16</sub>H<sub>12</sub>O<sub>10</sub>S
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Externe Identifikatoren/Datenbanken
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<table class="mw-collapsible mw-collapsed wikitable" data-expandtext="+" data-collapsetext="−" style="border-top:none; margin:-1px; width:calc(100% + 2px);">
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<td style="width:33%;"><a href="CAS-Nummer" title="CAS-Nummer">CAS-Nummer</a>
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<td><span title="Untervorlage eingebunden: CASRN"></span><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=549-31-5">549-31-5</a><span class="editoronly" style="display:none;"></span>
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<td><a href="PubChem" title="PubChem">PubChem</a>
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<td colspan="2"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/5487766">5487766</a>
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<td><a href="ChemSpider" title="ChemSpider">ChemSpider</a>
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<td colspan="2"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.4589518.html">4589518</a>
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<td style="border-right:1px solid #a2a9b1;"><a href="Wikidata" title="Wikidata">Wikidata</a>
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<td colspan="2"><a href="https://www.wikidata.org/wiki/Q83076766" class="extiw external" title="d:Q83076766">Q83076766</a>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Eigenschaften
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<td><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>
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<td>396,3 g·<a href="Mol" title="Mol">mol</a><sup>−1</sup>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Sicherheitshinweise
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<td colspan="2" style="text-align:center"><b><a href="Global_harmonisiertes_System_zur_Einstufung_und_Kennzeichnung_von_Chemikalien" title="Global harmonisiertes System zur Einstufung und Kennzeichnung von Chemikalien">GHS-Gefahrstoffkennzeichnung</a></b><br><i>keine Einstufung verfügbar</i><sup id="cite_ref-NV_1-0" class="reference"><a href="#cite_note-NV-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<td colspan="2" style="background:#FFDEAD; color:#202122; font-size:80%; text-align:center; line-height:150%; padding:.25em;">Wenn nicht anders vermerkt, gelten die angegebenen Daten bei <a href="Standardbedingungen" title="Standardbedingungen">Standardbedingungen</a> (0 °C, 1000 hPa).
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Persicarin</b> ist ein natürlich vorkommender <a href="Sulfate" title="Sulfate">Schwefelsäureester</a>. Er leitet sich von dem <a href="Flavonoide" title="Flavonoide">Flavonoid</a> <a href="Isorhamnetin" title="Isorhamnetin">Isorhamnetin</a> ab.
</p>
<div class="mw-heading mw-heading2"><h2 id="Vorkommen">Vorkommen</h2></div>
<p>Sulfate von Flavonoiden sind in Pflanzen weit verbreitet. Persicarin war der erste bekannte Vertreter, als es 1937 aus dem <a href="Wasserpfeffer" title="Wasserpfeffer">Wasserpfeffer</a> (<i>Polygonum hydropiper</i>) isoliert wurde.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Es kommt auch noch in weiteren Arten der Gattung <i><a href="Vogelkn%C3%B6teriche" title="Vogelknöteriche">Polygonum</a></i> sowie in <i><a href="Oenanthe_javanica" title="Oenanthe javanica">Oenanthe javanica</a></i> (Gattung Wasserfenchel) vor. Es wird meist als Kaliumsalz isoliert.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p><i><a href="In_vitro" title="In vitro">In vitro</a></i> zeigt Persicarin verschiedene biologische Aktivitäten. So wirkt es <a href="Antikoagulation" title="Antikoagulation">gerinnungshemmend</a>,<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> <a href="Neuroprotektion" title="Neuroprotektion">neuroprotektiv</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> und <a href="Entz%C3%BCndungshemmung" title="Entzündungshemmung">entzündungshemmend</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<div class="mw-references-wrap"><ol class="references">
<li id="cite_note-NV-1"><span class="mw-cite-backlink"><a href="#cite_ref-NV_1-0">↑</a></span> <span class="reference-text">Dieser Stoff wurde in Bezug auf seine Gefährlichkeit entweder noch nicht eingestuft oder eine verlässliche und zitierfähige Quelle hierzu wurde noch nicht gefunden.</span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Jeffrey B. Harborne: <cite style="font-style:italic">Flavonoid sulphates: A new class of sulphur compounds in higher plants</cite>. In: <cite style="font-style:italic">Phytochemistry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>14</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5–6</span>, Juni 1975, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1147–1155</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/S0031-9422%2800%2998585-6">10.1016/S0031-9422(00)98585-6</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Persicarin&rft.atitle=Flavonoid+sulphates%3A+A+new+class+of+sulphur+compounds+in+higher+plants&rft.au=Jeffrey+B.+Harborne&rft.date=1975-06&rft.doi=10.1016%2FS0031-9422%2800%2998585-6&rft.genre=journal&rft.issue=5-6&rft.jtitle=Phytochemistry&rft.pages=1147-1155&rft.volume=14" style="display:none"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">J. B. Harborne, Christine A. Williams: <cite style="font-style:italic">Notizen: A New Class of Flavone Pigments in the Palmae</cite>. In: <cite style="font-style:italic">Zeitschrift für Naturforschung B</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>26</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, 1. Mai 1971, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>490–490</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1515/znb-1971-0528">10.1515/znb-1971-0528</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Persicarin&rft.atitle=Notizen%3A+A+New+Class+of+Flavone+Pigments+in+the+Palmae&rft.au=J.+B.+Harborne%2C+Christine+A.+Williams&rft.date=1971-05-01&rft.doi=10.1515%2Fznb-1971-0528&rft.genre=journal&rft.issue=5&rft.jtitle=Zeitschrift+f%C3%BCr+Naturforschung+B&rft.pages=490-490&rft.volume=26" style="display:none"> </span></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Sae-Kwang Ku, Tae Hoon Kim, Jong-Sup Bae: <cite style="font-style:italic">Anticoagulant activities of persicarin and isorhamnetin</cite>. In: <cite style="font-style:italic">Vascular Pharmacology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>58</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, April 2013, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>272–279</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.vph.2013.01.005">10.1016/j.vph.2013.01.005</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Persicarin&rft.atitle=Anticoagulant+activities+of+persicarin+and+isorhamnetin&rft.au=Sae-Kwang+Ku%2C+Tae+Hoon+Kim%2C+Jong-Sup+Bae&rft.date=2013-04&rft.doi=10.1016%2Fj.vph.2013.01.005&rft.genre=journal&rft.issue=4&rft.jtitle=Vascular+Pharmacology&rft.pages=272-279&rft.volume=58" style="display:none"> </span></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Choong Je Ma, Ki Yong Lee, Eun Ju Jeong, Seung Hyun Kim, Junghyun Park, Yun Hee Choi, Young Choong Kim, Sang Hyun Sung: <cite style="font-style:italic">Persicarin from water dropwort (Oenanthe javanica) protects primary cultured rat cortical cells from glutamate‐induced neurotoxicity</cite>. In: <cite style="font-style:italic">Phytotherapy Research</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>24</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, Juni 2010, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>913–918</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/ptr.3065">10.1002/ptr.3065</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Persicarin&rft.atitle=Persicarin+from+water+dropwort+%28Oenanthe+javanica%29+protects+primary+cultured+rat+cortical+cells+from+glutamate%E2%80%90induced+neurotoxicity&rft.au=Choong+Je+Ma%2C+Ki+Yong+Lee%2C+Eun+Ju+Jeong%2C+...&rft.date=2010-06&rft.doi=10.1002%2Fptr.3065&rft.genre=journal&rft.issue=6&rft.jtitle=Phytotherapy+Research&rft.pages=913-918&rft.volume=24" style="display:none"> </span></span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Tae Hoon Kim, Sae‐Kwang Ku, Jong‐Sup Bae: <cite style="font-style:italic">Persicarin is anti‐inflammatory mediator against HMGB1‐induced inflammatory responses in HUVECs and in CLP‐induced sepsis mice</cite>. In: <cite style="font-style:italic">Journal of Cellular Physiology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>228</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, April 2013, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>696–703</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/jcp.24214">10.1002/jcp.24214</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Persicarin&rft.atitle=Persicarin+is+anti%E2%80%90inflammatory+mediator+against+HMGB1%E2%80%90induced+inflammatory+responses+in+HUVECs+and+in+CLP%E2%80%90induced+sepsis+mice&rft.au=Tae+Hoon+Kim%2C+Sae%E2%80%90Kwang+Ku%2C+Jong%E2%80%90Sup+Bae&rft.date=2013-04&rft.doi=10.1002%2Fjcp.24214&rft.genre=journal&rft.issue=4&rft.jtitle=Journal+of+Cellular+Physiology&rft.pages=696-703&rft.volume=228" style="display:none"> </span></span>
</li>
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